Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus
β Scribed by Austin L. Hughes; Mary Ann K. Hughes; Robert Friedman
- Book ID
- 116967816
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 193 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0168-1702
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Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. W e studied the cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytoto
## Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope An epitope that acted as a weak agonist in the cytotoxicity assay was identified as part of the capsid protein of a hepatitis C virus (HCV) variant. In a low concentration,