✦ LIBER ✦

Variable gene usage, physiology and development of Ly-1+ (CD5+) B cells

✍ Scribed by Richard R. Hardy

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 790 KB
Volume: 4
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(92)90010-c

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✦ Synopsis

Two related features of Ly-1+ B cells (CD5+ B cells in man) are their biased specificities and variable gene usage, and their relationship to the bulk of Ly-1- ('conventional') B cells. An emerging model views Ly-1+ B cells as a memory population in the adult animal, whose generation is largely limited to fetal and neonatal development. Selection based on germline-encoded self-reactivity then shapes the adult repertoire.

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