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Variable FHIT transcripts in non-neoplastic tissues

✍ Scribed by Ioannis Panagopoulos; Sofia Thelin; Fredrik Mertens; Felix Mitelman; Pierre Åman

Book ID
101260827
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
132 KB
Volume
19
Category
Article
ISSN
1045-2257

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✦ Synopsis

We used nested reverse transcriptase PCR to investigate the expression of the FHIT gene, a presumptive tumor suppressor gene located in chromosomal band 3p14.2, in non-neoplastic samples. Multiple transcripts of the FHIT gene were found in peripheral blood lymphocytes, skeletal muscle, and liver of healthy individuals, as well as in a cell line derived from synovial tissue. The data indicate that variable splicing of the FHIT transcript, leading to deletions of exons and thus anomalous or absent FHIT protein production, occurs frequently in non-neoplastic tissues. Hence, the finding of multiple nonfunctional FHIT transcripts is not tumor-specific and cannot be used as a genetic marker of neoplasia.

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