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Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease

โœ Scribed by B. Dermaut; G. Roks; J. Theuns; R. Rademakers; J. J. Houwing-Duistermaat; S. Serneels; A. Hofman; M. M. B. Breteler; M. Cruts; C. Van Broeckhoven; C. van Duijn


Publisher
Springer
Year
2001
Tongue
English
Weight
548 KB
Volume
248
Category
Article
ISSN
0340-5354

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โœ Corinne L. Lendon; Alonso Martinez; Isabel Maria Behrens; Kenneth S. Kosik; Luci ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 2 views

A single base substitution of a glutamic acid to an alanine codon 280 was found in the presenilin-1 (PS-1) gene on chromosome 14 in affected individuals in each of seven Colombian early-onset Alzheimer's disease (AD) kindreds. The mutation segregated with disease in kindreds tested. In the largest k