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Variable Dimerization of the Ly49A Natural Killer Cell Receptor Results in Differential Engagement of its MHC Class I Ligand

✍ Scribed by Julie Dam; James Baber; Alexander Grishaev; Emilio L. Malchiodi; Peter Schuck; Ad Bax; Roy A. Mariuzza


Book ID
116663172
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
645 KB
Volume
362
Category
Article
ISSN
0022-2836

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## Abstract Murine natural killer (NK) cells are inhibited by target cell MHC class I molecules __via__ Ly49 receptors. However, Ly49 receptors can be made inaccessible to target cell MHC class I by a __cis__ interaction with its MHC class I ligand within the NK cell membrane. It has recently been