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Variability in methotrexate serum and cerebrospinal fluid pharmacokinetics in children with acute lymphocytic leukemia: relation to assay methodology and physiological variables

✍ Scribed by Holger Seidel; Anders Andersen; Jan Terje Kvaløy; Randi Nygaard; Peter J Moe; Geir Jacobsen; Bo Lindqvist; Lars Slørdal

Book ID
114119729
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
113 KB
Volume
24
Category
Article
ISSN
0145-2126

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We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (