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Valproic acid teratogenicity in whole embryo culture is not prevented by zinc supplementation

โœ Scribed by Mary E. Coakley; Nigel A. Brown


Book ID
115778768
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
506 KB
Volume
35
Category
Article
ISSN
0006-2952

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โœ Constanze Lewandowski; Stephan Klug; Heinz Nau; Diether Neubert ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 369 KB

Pharmacokinetic studies were performed in connection with culture experiments. Using the technique of cultivating whole rat embryos of the early postimplantation stage, we measured the concentration of valproic acid (VPA) and 2-en-VPA in the culture medium (free and protein-bound form) and in embryo