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Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes

✍ Scribed by Caiying Wang; Zuo Luan; Yinxiang Yang; Zhaoyan Wang; Ying Cui; Guixiong Gu


Book ID
116773169
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
824 KB
Volume
497
Category
Article
ISSN
0304-3940

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## Abstract Trimethyltin (TMT) is a neurotoxicant known to induce early microglial activation. The present study was undertaken to investigate the role played by these microglial cells in the TMT‐induced neurotoxicity. The effects of TMT were investigated in monolayer cultures of isolated microglia