Valproic acid and active unsaturated metabolite (2-EN): Transfer to mouse liver following human therapeutic doses
✍ Scribed by Prof. Dr. Heinz Nau; Wolfgang Loscher
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 357 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
The transfer of valproic acid (VPA, 2-propylpentanoic acid) and its unsaturated active metabolite (2-en, 2-propyl-2-pentenoic acid) from plasma to liver has been studied in the mouse between 2 min and 6 h following oral administration of 50mg of the sodium salts per kg body weight. Transfer of both compounds was extremely rapid. Liver concentrations of VPA were higher than those in plasma, while liver concentrations of 2en were lower than those in plasma. The low hepatic levels of 2-en may be explained by extensive plasma protein binding of this metabolite. The liver/plasma concentration ratios were concentration-dependent, indicating the presence of active transport mechanisms and/or saturation of plasma protein binding. Our results indicate that 2-en should be further studied in regard to its potential for the induction of liver toxicity. The desirable low level of 2-en reached in the liver, seen together with previously observed favourableanticonvulsant profile and low teratogenicity, would indicate that this compound may be a valuable alternative antiepileptic agent.