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Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells

✍ Scribed by Amel Baya Bouzar; Mathieu Boxus; Julien Defoiche; Guy Berchem; Derek Macallan; Ruth Pettengell; Fenella Willis; Arsène Burny; Laurence Lagneaux; Dominique Bron; Bernard Chatelain; Christian Chatelain; Luc Willems


Book ID
108676038
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
445 KB
Volume
144
Category
Article
ISSN
0007-1048

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## Abstract B‐cell chronic lymphocytic leukaemia (B‐CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus r