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Valproate metabolite concentrations in brain increase with chronic administration of sodium valproate

✍ Scribed by G.F. Carl; Carolyn DeLoach; Jerome Patterson


Book ID
118340835
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
346 KB
Volume
37
Category
Article
ISSN
0024-3205

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The concentration of valproate was measured in plasma, CSF and brain tissue of patients who underwent resective surgical treatment because of severe temporal lobe epilepsy after pretreatment with either a sustained release formulation of valproate (Depakine Chrono; 5 patients), the conventional form