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Valproate-induced hyperammonemic encephalopathy in the presence of topiramate

✍ Scribed by Hamer, H. M.; Knake, S.; Schomburg, U.; Rosenow, F.


Book ID
119951259
Publisher
Lippincott Williams and Wilkins
Year
2000
Tongue
English
Weight
150 KB
Volume
54
Category
Article
ISSN
0028-3878

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## Abstract Six severe epileptic patients developed stuporous encephalopathy with marked cognitive impairment when topiramate (TPM) and sodium valproate (VPA) were coprescribed for five patients, and when monotherapy with TPM was introduced for one patient. In four patients, ammonaemia increased an