Valproate-induced hepatic failure in a case of cytochromecoxidase deficiency
β Scribed by B. Chabrol; J. Mancini; D. Chretien; P. Rustin; A. Munnich; N. Pinsard
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 263 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0340-6997
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π SIMILAR VOLUMES
We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 pg/ml for 20 hr. This regimen produces sever
## Abstract The influence of chronic hepatic failure on the disposition kinetics of valproate (VPA) excretion via a phase II reaction was examined in rats treated with carbon tetrachloride (1.0 mg/kg, s.c., 3 times a week) for 2 or 3 months. There was no significant difference in the plasma concent