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Valproate-induced hepatic failure in a case of cytochromecoxidase deficiency

✍ Scribed by B. Chabrol; J. Mancini; D. Chretien; P. Rustin; A. Munnich; N. Pinsard


Publisher
Springer
Year
1994
Tongue
English
Weight
263 KB
Volume
153
Category
Article
ISSN
0340-6997

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## Abstract The influence of chronic hepatic failure on the disposition kinetics of valproate (VPA) excretion via a phase II reaction was examined in rats treated with carbon tetrachloride (1.0 mg/kg, s.c., 3 times a week) for 2 or 3 months. There was no significant difference in the plasma concent