✦ LIBER ✦

Valproate and palmitate binding to serum albumin in valproate-treated patients. relation to obesity

✍ Scribed by Henrik Vorum; Lennart Gram; Bent Honoré

Book ID: 103932329
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 970 KB
Volume: 16
Category: Article
ISSN: 0920-1211
DOI: 10.1016/0920-1211(93)90040-e

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✦ Synopsis

Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P<O.OOOl) resulting in increased availability of long-chain fatty acids (P= 0.008) due to competitive valproate binding in the valproatetreated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy.

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