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Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease

✍ Scribed by Dénes Zádori; Andrea Geisz; Enikő Vámos; László Vécsei; Péter Klivényi


Book ID
113841827
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
308 KB
Volume
94
Category
Article
ISSN
0091-3057

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✍ Johannes Schiefer; G. Bernhard Landwehrmeyer; Hans-Gerd Lüesse; Arne Sprünken; C 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

Glutamate excitotoxicity has been suggested to contribute to the pathogenesis of Huntington's disease (HD). Riluzole is a substance with glutamate antagonistic properties that is used for neuroprotective treatment in amyotrophic lateral sclerosis and which is currently tested in clinical trials for