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Validity of spiral analysis in early Parkinson's disease

✍ Scribed by Rachel Saunders-Pullman; Carol Derby; Kaili Stanley; Alicia Floyd; Susan Bressman; Richard B. Lipton; Amanda Deligtisch; Lawrence Severt; Qiping Yu; Mónica Kurtis; Seth L. Pullman

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
306 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Spiral analysis is an objective, easy to administer noninvasive test that has been proposed to measure motor dysfunction in Parkinson disease (PD). We compared overall Unified Parkinson Disease Rating Scale Part III scores to selected indices derived from spiral analysis in seventy‐four patients with early PD (mean duration of disease 2.4 ± 1.7 years, mean age 61.5 ± 9.7 years). Of the spiral indices, degree of severity, first order zero crossing, second order smoothness, and mean speed were best correlated with total motor Unified Parkinson's Disease Rating Scale (UPDRS) score (all P < 0.01), and these indices showed a gradient across worsening tertiles of UPDRS (P < 0.05). Spiral indices also correlated with UPDRS ratings for the worst side and worst arm scores as well. The domains of bradykinesia, rigidity, and action tremor were correlated with first order crossing, second order smoothness, and mean speed, where as rest tremor was most highly correlated with degree of severity. This suggests that the spiral analysis may supplement motor assessment in PD, although further analysis of spiral metrics, a larger sample and longitudinal data should be evaluated. © 2007 Movement Disorder Society

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