✦ LIBER ✦
Validity of oral bioavailability estimates of phenolsulfonphthalein based on total urinary excretion from rats
✍ Scribed by S. T. Horhota; Ho-Leung Fung
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 236 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Urinary recovery of phenolsulfonphthalein from rats were determined after intracardial (0.075 mg) and oral (1.5 mg) doses. Although trace quantities of conjugated metabolites could be identified by TLC, the levels present did not introduce significant error into estimates of total phenolsulfonphthalein excretion if samples were assayed directly by colorimetric methods for only unchanged dye. The absolute availability of phenolsulfonphthalein based on urinary recovery under the present experimental conditions was estimated at 10.6%.