✦ LIBER ✦

Validity of family history for the diagnosis of dementia among siblings of patients with late-onset Alzheimer's disease

✍ Scribed by G. Devi; K. Marder; P.W. Schofield; M.X. Tang; Y. Stern; R. Mayeux

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 31 KB
Volume: 15
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1998)15:3<215::aid-gepi1>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

We examined 180 siblings of 127 probands with probable or possible Alzheimer's dementia (AD) in a family study of AD. The overall sensitivity of a simple family history questionnaire was 64% and the specificity was 84%. Sensitivity improved 90-100% with minimal decline in specificity when we considered clinic-based vs. population survey patients. Higher education among informants and the availability of a spouse or a sibling as informant significantly increased sensitivity. Awareness of such factors may improve the yield of the family history in AD using a simple questionnaire.

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