Validation of the Sapporo criteria for antiphospholipid syndrome

✍ Scribed by Michael D. Lockshin; Lisa R. Sammaritano; Sergio Schwartzman

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 44 KB
• Volume: 43
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/1529-0131(200002)43:2<440::aid-anr26>3.0.co;2-n

✦ Synopsis

Objective. To test the Sapporo criteria for the classification of the antiphospholipid syndrome (APS).

Methods. We classified 243 consecutive patients who had clinical diagnoses of primary APS (n ‫؍‬ 49), secondary APS (n ‫؍‬ 26), systemic lupus erythematosus (SLE) without clinical APS (n ‫؍‬ 131), and lupus-like disease without clinical APS (n ‫؍‬ 37).

Results. Sensitivity, specificity, positive predictive value, and negative predictive value were 0.71, 0.98, 0.95, and 0.88, respectively. False-negative findings were the result of patients being classified on the basis of minor criteria that were not included in the Sapporo criteria, such as livedo reticularis, thrombocytopenia, low-titer IgG or IgM anticardiolipin antibody, IgA anticardiolipin antibody, and anti-␤ 2 -glycoprotein I antibody. Some patients with false-negative results were true seronegative cases.

Conclusion. The Sapporo criteria for APS compare favorably with the American College of Rheumatology criteria for SLE and are usable for clinical studies.