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Validation of HB-EGF and amphiregulin as targets for human cancer therapy

โœ Scribed by Fusanori Yotsumoto; Hiroshi Yagi; Satoshi O. Suzuki; Eiji Oki; Hiroshi Tsujioka; Touru Hachisuga; Kenzo Sonoda; Tatsuhiko Kawarabayashi; Eisuke Mekada; Shingo Miyamoto

Book ID
116295959
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
200 KB
Volume
365
Category
Article
ISSN
0006-291X

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โœ Hitoshi Funatomi; Jun Itakura; Toshiyuki Ishiwata; Ira Pastan; Stewart A. Thomps ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 152 KB ๐Ÿ‘ 2 views

Human pancreatic cancers overexpress the epidermal growth factor (EGF) receptor (EGFR) and all 5 ligands that bind to this receptor, including amphiregulin. It is not known, however, whether amphiregulin contributes in an autocrine manner to enhance pancreatic cancer cell growth. Therefore, we used