Validation of benzodiazepine Ξ²-glucuroni
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Carol L. O'Neal; Alphonse Poklis
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Article
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1996
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Elsevier Science
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English
β 848 KB
The major metabolite of hydroxylated benzodiazepines is the P-glucuronide metabolite, thus a hydrolysis step is included in benzodiazepine analyses in urine. We evaluated the new Alltech (R,S) oxazepam and lorazepam P-glucuronide primary reference materials as hydrolysis controls and for use in prof