Validation of an amperometric high-performance liquid chromatographic determination of epinephrine in bupivacaine and epinephrine injection
β Scribed by Terry D. Wilson
- Book ID
- 108336120
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 485 KB
- Volume
- 498
- Category
- Article
- ISSN
- 1873-3778
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A reversed-phase, high-performance liquid chromatographic (HPLC) procedure, which is specific and quantitative for lidocaine hydrochloride, epinephrine, and methylparaben, was developed for the analysis of lidocaine hydrochloride and lidocaine hydrochloride with epinephrine solutions for injection.
The separation by HPLC of basic drugs on silica-based reversed phases remains a major problem because of the interaction between the residual silanol groups of the silica and the amino function of the drug. This paper describes the validation of HPLC methods for the determination of two injectable s