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Validation of a non-invasive technique to assess development of airway hyperreactivity in an animal model of immunologic pulmonary hypersensitivity

โœ Scribed by David A. Griffiths-Johnson; Meryl H. Karol

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
547 KB
Volume
65
Category
Article
ISSN
0300-483X

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โœ J. Pauluhn; A. Eben ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 695 KB

Conscious Hartley guinea-pigs were sensitized with trimellitic anhydride (TMA) or trimeric hexamethylene diisocyanate biuret (Des-N) by repeated intradermal injections or by inhalation exposure. Immediate-and delayed-onset pulmonary reactions were recorded during/after challenges with the hapten or