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Validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of Sotrastaurin and its metabolite N-desmethyl-sotrastaurin in human blood

✍ Scribed by Annamaria Jakab; Serge Winter; Bertrand Guy; Marc Raccuglia; Frank Picard; John M. Kovarik; Jayraj Chudasama; Swati Guttikar; Puran Singhal; Olivier Kretz


Book ID
113687725
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
547 KB
Volume
897
Category
Article
ISSN
1873-376X

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## Abstract A simple and sensitive liquid chromatography‐tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the quantitation of exemestane (Exe) and its main metabolite 17‐dihydroexemestane (DhExe) in human plasma. The analytes were extracted by protein precipitation wi