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Validated hydrophilic interaction LC-MS/MS method for determination of 2-pyrrolidinone residue: applied to a depletion study of 2-pyrrolidinone in swine liver

✍ Scribed by Yanhong Liu; Ximing Chen; Yanhong Ji; Jiangtao Chen; Guangxiang Wang; Youjun Shang; Xiangtao Liu; Jack Pan

Publisher
Springer
Year
2010
Tongue
English
Weight
357 KB
Volume
399
Category
Article
ISSN
1618-2650

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## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i