Vaginal cycles in the rat after x-ray or other damage to one or both ovaries

✍ Scribed by Plagge, James C. ;Krehbiel, Robert H.

• Publisher: John Wiley and Sons
• Year: 1962
• Tongue: English
• Weight: 608 KB
• Volume: 144
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1091440403

✦ Synopsis

Abstract

Damage to the rat ovary at 60 days of age causes irregularities in the estrous cycle and leads to continuous cornification of the vagina. These vaginal changes occurred within two to three months after bilateral irradiation (800 or 2,000 r) or after bilateral castration and autotransplantation of a portion of one ovary. Unilateral irradiation or ligation of the ovarian arteries at their junction with the uterine artery produces similar changes within five to seven months. Comparable vaginal changes did not occur in control animals until they reached the age of ten months.