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Vacuolar myopathies in adults with myalgias: Value of paraspinal muscle investigation

✍ Scribed by J. Terry Petrella; Michael J. Giuliani; David Lacomis

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 115 KB
Volume: 20
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199710)20:10<1321::aid-mus18>3.0.co;2-5

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✦ Synopsis

We evaluated 4 women with chronic fatigue and myalgias. Two had proximal weakness. All had elevated serum creatine kinase levels, but none was diagnosed with myopathy until electrodiagnostic studies revealed myotonic or complex repetitive discharges predominantly in paraspinal muscles. Histopathology of paraspinal muscles revealed vacuolar myopathies with glycogen storage; biochemical assays revealed phosphorylase deficiency in 1. Since vacuolar myopathies may affect paraspinal muscles more than limb muscles, electromyographic and histopathologic studies of paraspinal muscles may be required for diagnosis.

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