History, precedent, and progress in the
โ
Maurice R. Hilleman
๐
Article
๐
1990
๐
John Wiley and Sons
๐
English
โ 908 KB
## Abstract The use of cell substrates to propagate viruses or recombinant plasmids for vaccine productions has been the subject of long evolutionary conflict, primarily from the standpoint of product safety, and especially from the viewpoint of cancer induction. The present concern is for safety