✦ LIBER ✦

Vaccine-induced CD8+ T cells eliminate tumors by a two-staged attack

✍ Scribed by Kowalczyk, Dariusz W; Wlazlo, Anthony P; Giles-Davis, Wynetta; Kammer, Andreas R; Mukhopadhyay, Sunil; Ertl, Hildegund CJ

Book ID: 110019059
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 262 KB
Volume: 10
Category: Article
ISSN: 0929-1903
DOI: 10.1038/sj.cgt.7700653

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Regulation of vaccine-induced anti-tumor

Regulation of vaccine-induced anti-tumor immunity by CD4+CD25+ T cell hybridomas

✍ David Lubaroff; Jeanne Howard; Mohamed Nasr; Elizabeth Field 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 25 KB

Blockade of TGF-β enhances tumor vaccine

Blockade of TGF-β enhances tumor vaccine efficacy mediated by CD8+ T cells

✍ Shun Takaku; Masaki Terabe; Elena Ambrosino; Judy Peng; Scott Lonning; John M. M 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 264 KB

## Abstract Though TGF‐β inhibition enhances antitumor immunity mediated by CD8^+^ T cells in several tumor models, it is not always sufficient for rejection of tumors. In this study, to maximize the antitumor effect of TGF‐β blockade, we tested the effect of anti‐TGF‐β combined with an irradiated

DNA vaccination with T-cell epitopes enc

DNA vaccination with T-cell epitopes encoded within Ab molecules induces high-avidity anti-tumor CD8+ T cells

✍ Victoria A. Pudney; Rachael L. Metheringham; Barbara Gunn; Ian Spendlove; Judith 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 501 KB

## Abstract Stimulation of high‐avidity CTL responses is essential for effective anti‐tumor and anti‐viral vaccines. In this study we have demonstrated that a DNA vaccine incorporating CTL epitopes within an Ab molecule results in high‐avidity T‐cell responses to both foreign and self epitopes. The

Optimized DNA vaccines to specifically i

Optimized DNA vaccines to specifically induce therapeutic CD8 T cell responses against autochthonous breast tumors

✍ Hyun-Il Cho; Guilian Niu; Norma Bradley; Esteban Celis 📂 Article 📅 2008 🏛 Springer-Verlag 🌐 English ⚖ 378 KB

Branched and linear lipopeptide vaccines

Branched and linear lipopeptide vaccines have different effects on primary CD4+ and CD8+ T-cell activation but induce similar tumor-protective memory CD8+ T-cell responses

✍ Adriana Baz; Kathy Buttigieg; Weiguang Zeng; Michael Rizkalla; David C. Jackson; 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 712 KB

Paradoxical enhancement of CD8 T cell-de

Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine

✍ Dev Karan; Arthur M. Krieg; David M. Lubaroff 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 371 KB 👁 1 views

## Abstract Generation of antigen‐specific CD8+ T cell responses is considered optimal for an effective immunotherapy against cancer. In this study, we provide a proof of principle that __in vitro__ observed diminished CD8+ T cell response provided a strong __in vivo__ tumor protection. Immunizatio