Peptides derived from mutated ras are immunogenic in mice and humans, and represent a group of specific tumor antigens that are potential targets for immunotherapy. T-cell responses against mutant p2I ras can be initiated in vitro by repeated stimulation of peripheral-blood mononuclear cells with mu
✦ LIBER ✦
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation
✍ Scribed by M.K. Gjertsen; J. Breivik; I. Saeterdal; E. Thorsby; G. Gaudernack; A. Bakka; O. So̸reide; B.G. Solheim
- Book ID
- 118559430
- Publisher
- The Lancet
- Year
- 1995
- Tongue
- English
- Weight
- 316 KB
- Volume
- 346
- Category
- Article
- ISSN
- 0140-6736
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Mutant p21-ras proteins contain sequences that distinguish them from normal ras, and represent unique epitopes for T-cell recognition of antigen-bearing tumour cells. Here, we examined the capacity of CD4 ؉ and CD8 ؉ T cells, generated simultaneously by mutant-ras-peptide vaccination of a pancreatic