Vaccination as immunotherapy for B cell lymphoma

✍ Scribed by Joachim L. Schultze

• Book ID: 101278617
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 161 KB
• Volume: 15
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/(sici)1099-1069(199708)15:3<129::aid-hon607>3.0.co;2-n

✦ Synopsis

Current therapy does not cure the majority of patients with B cell non-Hodgkin's lymphoma (NHL) and further intensification does not benefit the patient. Therefore, new approaches are necessary. Immunotherapy has become again a major interest as a new treatment modality for B cell lymphoma since the discovery that the lymphoma specific Id can be presented to antigen-specific T cells. Vaccination of the tumour-bearing host is one of the major strategies to induce a T cell mediated anti-tumour immunity in vivo. For B cell lymphomas the lymphoma specific Id can be used as a tumour-specific antigen to stimulate T cells. Alternatively, the malignant B cells can be modified to become efficient antigen presenting cells (APCs) and present peptides from their own tumour-specific antigens to the autologous T cells. Currently explored and future vaccination strategies for B cell lymphoma will be discussed here.