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UVA- and UVB-induced changes in hairless mouse skin collagen

โœ Scribed by F. Trautinger; K. Mazzucco; R. M. Knobler; A. Trenz; E. -M. Kokoschka

Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
544 KB
Volume
286
Category
Article
ISSN
0340-3696

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โœฆ Synopsis

UVA-and UVB-induced alterations in dermal collagen were investigated in a murine animal model. Groups of hairless mice were exposed to UVA and UVB for 28 weeks at a dose of 60 J/cm z three times weekly and 0.06 J/cm 2 three times weekly, respectively. Untreated animals were used as controls. Every 4 weeks dorsal skin was examined for quantitative and qualitative changes in dermal collagen. Neither UVA nor UVB caused a significant alteration in total skin collagen content. However, after UVA treatment the ability of skin collagen to be digested by pepsin decreased dramatically (up to 65 % of skin collagen remained insoluble after 4 months), whereas exposure to UVB had no significant effect. Furthermore a shift in the ratio of ttl(I,1II) chains to tt2(I) chains was detected after UVA exposure. The amount of type V collagen in mouse skin, as determined by a sensitive ELISA method, was markedly decreased after UVA treatment, but not after UVB treatment.

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