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UV-specific mutations of the human patched gene in basal cell carcinomas from normal individuals and xeroderma pigmentosum patients

✍ Scribed by Leela Daya-Grosjean; Alain Sarasin

Book ID
114070194
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
228 KB
Volume
450
Category
Article
ISSN
0027-5107

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Mutation analysis of the human homologue
Mutation analysis of the human homologue of drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin
✍ Lena K. Eklund; Erika Lindström; Anne Birgitte Undén; Barbro Lundh-Rozell; Mona 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 543 KB

The human homologue of Drosophila patched (PTCH), located at chromosome 9q22.3, was recently identified as a candidate tumor suppressor gene for familial and sporadic basal cell carcinomas. Squamous cell carcinomas (SCCs) of the skin display allelic loss in this chromosomal region, which, in additio