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Uv-induced but P53 independent apoptotic death in CHO.K1 cells is promoted by M phase inhibitors

✍ Scribed by Bor-Show Tzang; Yi-Chyi Lai; Yin-Chang Liu


Book ID
107427631
Publisher
Society for In Vitro Biology
Year
1999
Tongue
English
Weight
157 KB
Volume
35
Category
Article
ISSN
1475-2689

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## Abstract Tumor suppressor p53 is an essential regulator in mammalian cellular responses to DNA damage including cell cycle arrest and apoptosis. Our study with Chinese hamster ovary CHO‐K1 cells indicates that when p53 expression and its transactivation capacity was inhibited by siRNA, UVC‐induc