UV curable bioadhesives: Copolymers ofN-vinyl pyrrolidone

✍ Scribed by Kao, Fu-Jung ;Manivannan, Gurusamy ;Sawan, Samuel P.

• Book ID: 101256942
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 83 KB
• Volume: 38
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199723)38:3<191::aid-jbm2>3.0.co;2-k

✦ Synopsis

A series of UV curable bioadhesives was prepared from copolymers of Nvinyl pyrrolidone with four different comonomers: 2-acrylamido methyl 1-propane sulfonic acid, vinyl succinimide, glycidyl acrylate, and 2-isocyanatoethyl methacrylate. The developed bioadhesives demonstrated a fast UV-induced setting with a set time of about 3 min. Bond strength between the bioadhesive and porcine intestine specimen was determined by the peel test. These bioadhesives can provide improved adhesion values up to 4.6 N/m of 180Њ peel strength compared to five different commercial bioadhesives (values ranging from 0.52 to 3.04 N/m). In addition, the fully hydrated UV curable bioadhesives have shown a high water uptake ranging from 25 to 350 wt% and equilibrium water content ranging from 20 to 100 wt%. Because N-vinyl pyrrolidone is a monomer all these copolymers are expected to retain good biocompatibility. Obtained promising results of peel strength and water uptake clearly suggest that the developed bioadhesives have a strong potential for many medical applications such as single-layered hydrogel wound dressings and tissue adhesives.