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Utilizing automated methods to improve estimates of recurrence risk with linked genetic markers

✍ Scribed by Price, R. Arlen ;Kidd, Kenneth K. ;Opitz, John M.

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 310 KB
Volume: 17
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320170311

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✦ Synopsis

Information on linked markers can greatly improve estimates of recurrence risk for genetic disorders. However, when linkage is incomplete, utilizing the information in genetic counseling requires complex, repetitive calculations to estimate correct risks whenever the parental linkage phase is not precisely known. This paper demonstrates with examples how the computer program LIPED can be used for any pedigree to estimate risk precisely within bounds determined only by confidence limits on the recombination fraction.

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✍ Rebbeck, T. R.; Jordan, H. A.; Schnur, R. E.; Rogatko, A. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB 👁 1 views

We apply a method proposed by Rogatko et al. [1995: Am J Med Genet 59:24-32] to estimate carrier risks using genetic linkage data. The method is illustrated for X-linked ocular albinism. Linkage data from pedigrees were combined with genome mapping data to compute carrier risks for individuals with