✦ LIBER ✦
Utilization ofin vivoalkylated metabolites as a possible cause of increased sensitivity of tumor cells to alkylating agents
✍ Scribed by M. I. Lerman; O. Yu. Abakumova; N. G. Kutcenko; I. S. Sokolova; L. B. Gorbacheva; A. M. Serebryannyi
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 342 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0301-4851
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✦ Synopsis
In this paper it is shown that the cells of hepatoma 22a utilize alkylated metabolites, which are formed in vivo after a single injection of MNU. These antimetabolites are efficiently incorporated into tumor DNA, RNA and proteins.
Abbreviations. MNU, N-methyl-N-nitroso-urea; TCA, trichloroacetic acid. Molecular Biology Reports 2 (1975) 151-157. All Rights Reserved Copyright 9 by D. Reidel Publishing Company, Dordrecht.Holland.