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Utilization of O-xylylene N,N-diethylphosphoramidite for the synthesis of phosphoric diesters

✍ Scribed by Yutaka Watanabe; Yasunobu Komoda; Shoichiro Ozaki


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
263 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis


o-Xylylene alkyl phosphites which were derived by the reaction of alcohols with o-xylylene N,Ndiethylphosphommidite in the presence of IrI-tetrazole wcrc reacted with second alcohols in the presence of pyridinium bromide perbromide, and a letiamine, to give the corresponding triesters involving phospholipids. The esters were deprotected to phosphoric diesters by hydrogcnolysis or the reaction with d&odium disulfide.


πŸ“œ SIMILAR VOLUMES


Di-t-butyl N, N-diethylphosphoramidite a
✍ John W. Perich; R.B. Johns πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 238 KB

A8 an alternative to the use of dibenzyl and di-&-butyl phosphorohalidates for the phosphorylation of alcohols.1-3 our reoent studies have ooncentrated on the use of dialkyl &&diethylphosphoramidites for the efficient phosphorylation OP alcohols and hydroxycontaining biomoleoules. In particular, we