𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Utilization of lymphoid cells with inserted IL-2 gene for immunotherapy of cancer

✍ Scribed by J. Bubenik; J. Simová; M. Indrová; D. Bubeniková

Book ID
119157471
Publisher
Elsevier Science
Year
1991
Weight
156 KB
Volume
27
Category
Article
ISSN
0277-5379

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IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D I22 clone. Both high and low D 122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumor