Use of an established human hepatoma cel
โ
George Chang; David Jacobson-Kram; Jerry R. Williams
๐
Article
๐
1988
๐
Springer
๐
English
โ 761 KB
Genetic toxicology assays that rely on $9 microsomal mixes are subject to artifacts related to the generation of mutagenic metabolites by acidic p Hs, variation in individual isolations of microsomes and the failure of subcellular fractions to faithfully produce metabolites generated in intact cells