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Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials

✍ Scribed by Nadine Houede; Peter F. Thall; Hoang Nguyen; Xavier Paoletti; Andrew Kramar


Book ID
109224235
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
175 KB
Volume
66
Category
Article
ISSN
0006-341X

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Phase II clinical trial of parenteral hy
✍ Jonathan J. Beitler; Richard V. Smith; Randall P. Owen; Carl E. Silver; Madhu Ma πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 398 KB πŸ‘ 2 views

## Abstract ## Background Almost all concurrent chemoradiation regimens for head and neck are platinum based; however, cisplatin is associated with severe renal, oto‐, and neurotoxicity. Hydroxyurea (HU) has been associated with fewer irreversible toxicities. We obtained HU in parenteral form to b