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Uteroferrin: A protein in search of a function

✍ Scribed by R. Michael Roberts; Fuller W. Bazer

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 566 KB
Volume: 1
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950010106

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Uteroferrin, a purple‐colored, iron‐containing acid phosphatase, with many of the properties of a lysosomal hydrolase, transports iron from the mother to the conceptus in pregnant pigs. Uteroferrin, however, is but one member of what may be a broad class of iron‐containing phosphatases with unusual spectral properties which result from a novel type of di‐iron active site. The biological function of uteroferrin is unknown. We argue here that the in vivo function of uteroferrin, despite its undoubted ability to act as a potent acid phosphatase, is that of a transplacental iron transporter.

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