Uterine motility in the reptileAnolis carolinensis: interactive effects of tension, prostaglandins, calcium, and vasotocin
✍ Scribed by Jones, Richard E. ;Lopez, Kristin H. ;Austin, Harriet B. ;Orlicky, David J. ;Summers, Cliff H.
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 160 KB
- Volume
- 305A
- Category
- Article
- ISSN
- 1548-8969
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✦ Synopsis
Uteri of Anolis carolinensis exhibited spontaneous rhythmic contractions in vitro. Addition of arginine vasotocin (AVT) caused an immediate, strong, tonic contraction followed by rhythmic contractions with the same frequency as spontaneous contractions but of a greater amplitude. At low tension (1.5 g) the AVT-induced tonic contraction was blocked by low dose of indomethacin, suggesting that it is influenced by calcium rather than prostaglandins (PGs). An increase in tension (from 1.5 to 15 g) reduced the duration of the AVT-induced tonic contraction; this stretch-induced decrease was also blocked by indomethacin. Stretch also decreased the duration of the rhythmic contractions, but this stretch effect was not inhibited by indomethacin. The rest interval between rhythmic contractions was decreased by PGF 2a and PGE 2 , and indomethacin or stretch blocked these PG effects. Indomethacin, AVT, or stretch alone did not affect PGF 2a secretion from AVT-treated uteri. Stretch also reduced PGF 2a secretion from AVT-treated uteri, an effect inhibited by indomethacin.