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Uterine leiomyosarcomas are driven by cell cycle deregulation

โœ Scribed by J. Barlin; M. Leitao; L. Qin; M. Bisogna; N. Olvera; K. Shih; M. Hensley; G. Schwartz; J. Boyd; D. Levine


Book ID
113963884
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
64 KB
Volume
125
Category
Article
ISSN
0090-8258

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## Abstract Brk is a cytoplasmic nonreceptor tyrosine kinase that is overexpressed in breast tumors but undetectable in normal or benign mammary tissues. Brk promotes proliferation of human mammary epithelial cells and tumor growth in a mouse model, but the role of Brk in cell cycle regulation is n