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USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis

✍ Scribed by Mingli Xu; Masakatsu Takanashi; Kosuke Oikawa; Masami Tanaka; Hirotaka Nishi; Keiichi Isaka; Motoshige Kudo; Masahiko Kuroda


Book ID
116299041
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
398 KB
Volume
388
Category
Article
ISSN
0006-291X

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## Abstract In bone, a large proportion of osteoblasts, the cells responsible for deposition of new bone, normally undergo programmed cell death (apoptosis). Because mechanical loading of bone increases the rate of new bone formation, we hypothesized that mechanical stimulation of osteoblasts might