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Using support vector machines for prediction of protein structural classes based on discrete wavelet transform

✍ Scribed by Jian-Ding Qiu; San-Hua Luo; Jian-Hua Huang; Ru-Ping Liang

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 211 KB
Volume: 30
Category: Article
ISSN: 0192-8651
DOI: 10.1002/jcc.21115

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✦ Synopsis

Abstract

The prediction of secondary structure is a fundamental and important component in the analytical study of protein structure and functions. How to improve the predictive accuracy of protein structural classification by effectively incorporating the sequence‐order effects is an important and challenging problem. In this study, a new method, in which the support vector machine combines with discrete wavelet transform, is developed to predict the protein structural classes. Its performance is assessed by cross‐validation tests. The predicted results show that the proposed approach can remarkably improve the success rates, and might become a useful tool for predicting the other attributes of proteins as well. © 2008 Wiley Periodicals, Inc. J Comput Chem 2009

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