Clinicians have long observed that treatment with one anticancer drug can confer resistance to that drug and to other anticancer drugs with different chemical structures and mechanisms of action. This is the multidrug resistance (MDR) phenomenon, which frequently occurs in the absence of previous ch
Using purified P-glycoprotein to understand multidrug resistance
β Scribed by Adam B. Shapiro; Victor Ling
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 641 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0145-479X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Multidrug resistance (MDR) is a major obstacle to the effective treatment of cancer. Cellular overproduction of Pβglycoprotein (Pβgp), which acts as an efflux pump for various anticancer drugs (e.g. anthracyclines, Vinca alkaloids, taxanes, epipodophyllotoxins, and some of the newer ant
In the past year, our understanding of the biology and molecular basis of multidrug resistance of tumours has advanced on several fronts. Intriguing clues to some of the key questions in the area provide optimism for future understanding and, with luck, eventual prevention and/or treatment.