Using protein-ligand docking to assess the chemical tractability of inhibiting a protein target
โ Scribed by Richard A. Ward
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 751 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1610-2940
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Proteinโligand docking has made important progress during the last decade and has become a powerful tool for drug development, opening the way to virtual high throughput screening and __in silico__ structureโbased ligand design. Despite the flattering picture that has been drawn, recent
We have constructed chimaeric genes consisting of sequences encoding the transit peptide and 4, 16, 24, 53 or 126 amino-terminal residues of the mature chlorophyll a/b binding (Cab) apoprotein fused to the Escherichia coli gene encoding beta-glucuronidase (GUS). These genes were introduced into toba
## Abstract Dilated cardiomyopathy (DCM) is a leading cause of endโstage heart failure and cardiac transplantation. Anticardiac antibodies are common and removal of these through immunoadsorption (IA) is associated with improvement in global cardiac function. The effect of IA on regional function a
It is shown that the computer program LUDI can be used to search large databases of three-dimensional structures for putative ligands of proteins with known 3D structure. As an example, a subset of =30 000 small molecules (with less than 40 atoms and 0-2 rotatable bonds) from the Fine Chemicals Dire