Optimization of surface modifications of
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Toshikazu Tanaka; Yu-Long Sun; Chunfeng Zhao; Mark E. Zobitz; Kai-Nan An; Peter
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Article
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2006
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Elsevier Science
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English
โ 270 KB
Previous studies have shown that the carboxyl groups in hyaluronic acid (HA) could be activated by 1-ethy 1-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) to form intermediate O-acylisoureas, which can chemically bind to exposed amino groups on the tendon surfa