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Using MT−/− mice to study metallothionein and oxidative stress

✍ Scribed by Craig.C. Conrad; David T. Grabowski; Christi A. Walter; Marian Sabia; Arlan Richardson

Book ID
114277820
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
267 KB
Volume
28
Category
Article
ISSN
0891-5849

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Tolerance to cadmium hepatotoxicity by metallothionein and zinc: in vivo and in vitro studies with MT-null mice
✍ Peter Coyle; Geralt Niezing; Tanya L. Shelton; Jeffrey C. Philcox; Allan M. Rofe 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 168 KB

The protective role of metallothionein (MT) in Cd-mediated hepatotoxicity was investigated in vivo and in vitro. Following injection of Cd (2 mg/kg, intraperitoneal or subcutaneous) hepatoxicity was significantly greater at 20 h in metallothionein-null (MT -/-) mice, compared with controls (MT+/+).